Hmmm...it really depends. How am I going to die? How are these 10,000 strangers going to die? If I say no will family members be so enraged and try to kill me anyway?
Its really hard to sacrifice yourself for people you don't know. There are so many people born everyday and even though you are a person, without knowing you, I will just see you as another number added to the world population. So for the most part I'd say no.
ALSO: another interesting thing I noticed. If someone asked me to chose between a loved one like my mother versus the lives of 10,000 people....I'd chose my mom in a heartbeat without even thinking it through as I would if it were me being sacrifices