If it wasn't for Brutasha, I'd still have hope for a Cap/Widow pairing. They're just so great together, and it's not uncommon for people to end up together after being close friends for a long time. It's not like Cap was "friend zoned".
Alas, that ship has sailed and Widow is now tied to the Hulk. Unfortunate, because I don't really see that relationship going anywhere in the future, and I'd hate for the sappy love story to further harm the two characters in CW/IW, because it certainly did in AOU. Damn you Whedon