I'd probably draw the occasional character to look like an actor I think has the same look, but I wouldn't do it with every character, and I wouldn't make it too obvious.
For example, Scot Eaton jumped into the X-Men books during Messiah CompleX. Throughout that story, he kept drawing Patrick Stewart's face for Professor X. It was a little jarring at first, but I got used to it. Not something I'd recommend artists do too often. However, when Eaton was drawing those first few issues of X-Men Legacy, he started drawing Professor X to look a little like Leonard Nimoy, and that face was strangely perfect for Xavier.