Actors, no. Performers want their big break, at least when they're coming up, and will take the risk of cruel scrutiny to break in. And sometimes, if they're established, they just want a good role or opportunity (like every actor who's played Joker, or even probably the financial reasons Tom Hardy is Venom).
With that said, directors I do believe are being scared off. Or rather established directors who still prefer some autonomy and creative control to attempt something grander than just a product. Plenty of hungry young directors, for the same reasons as above, agree to work inside the Marvel system for example. But directors who still strive to excel and make something that towers above the pack, like Mangold or McQuarrie as this thread starts with, I do believe will increasingly step away from franchised brands. Especially as they become more about "universe" building and all having a uniform look.
Consider 15 or so years ago we were getting very distinct and seasoned voices like Christopher Nolan, Sam Raimi, and Bryan Singer as directors. I think time has revealed Singer is not nearly as good as the first two (on or off screen), but at the time he was still the guy who made Usual Suspects. Now once in a while we still get Ryan Coogler or Taika Waititi, but their movies feel less "theirs" and more their take on the Marvel formula. A major exception to this is James Gunn... and well, look what happened to him.
I imagine the same will hold true with Star Wars after the way Rian Johnson was treated by fans, and Lord and Miller were treated by Lucasfilm. I think increasingly direction in big studio tentpoles will become more of a TV-like gig. Something where they need a pro to steer the ship, but one who has no say in where it is headed or what kind of ship it is.
Many fans will say that's "fine." But the studio system is already more than halfway there, and there's a reason Mission: Impossible - Fallout felt so fresh and invigorating after a summer of such filler.