Well, I did have this idea:
Inspector Gadget is the hero and mascot of the Metro City police department. While quite clumbsy and often rather clueless, his sheer dumb luck, many gadgets, and assistance from his slightly more adept allies usually results in his cases ending succesfully, and his "never say die" aditude has made him a hero in the eyes of the public. He was origionally John Brown, a security officer who worked at a scientific reaserch facility. When the facility was robbed and set ablaze by members of the international crime syndicate known as MAD, John risked his life to save that of Doctor Slickstein. Injured in the fire, John is "rebuilt" by Slickstein, who then goes into hiding shortly afterwards. John becomes a member of the MCPD, and is soon known as Inspector Gadget. Gadget quickly gets caught up with the FBI's atempts to bring down MAD, which is based in Metro City and has ties to criminal activity all over the world. The feds have been trying to take down Mad for over a decade, and have a casefile on them as thick as an encyclopedia set. Still, they don't know what MAD stands for. Through all of this, he is aided by his super genius neice Penny and their freakishly human like dog Brain. He also has an uneasy relationship with Snake, a vaguley psychotic reporter for the Metro City Daily Press who is regularly trying to "take on the system" and dig up some dirt on Gadget (Transmetropolitan reference).
Soon, Gadget is drafted by the military into there "Posthuman Project," a government sponsired special ops. team of superhumans (reference to both The Ultimates and Supreme Power). Some members featured are Commander Apollo, a jingoistic patriot with anger issues and a severe lack of faith in humanity who was given super powers by being fused with alien DNA, and Nightblade, a nigh indestructible, somewhat racist special ops agent who often contemplates murdering his teammates so he can make a move on their girlfriends. All of the characters on the team are "Ultimate" parodies of the various Amalgam Comics characters, often being amalagamations of Ultimate and Supreme Power characters.
Sufice to say, Gadget's tenure on the team is a short one, and he soon goes back to fighting crime and trying to bring down MAD in Metro City. However, everything changed when Gadget is captured by MAD. There, he is cut open and thoroughly inspected by none other than Doctor Slickstein. Slickstein is in fact a member of MAD who faked the robbery of his lab and atempt on his life to create an excuse for dissapeating from the public eye. He not only informs Gadget that he's never seen him before, but that his body has no organics in it. He's made up entirely of random electronic parts that seems to be manipulated by some kind of strange elctromagnetic feild into serving whatever Gadget's needs are (thus explaining his seemingly limitless supply of gadgets). Gadget escapes, but is deeply troubled by the news. What makes matters worse is that, when he gets home, Brain starts talking.
Brain reveals to Gadget that he used to be Brian Callahan, a pessemistic and sardonic mystic, private detective, paranormal investigator, and con man (a parody of John Constantine, to be percise) who was cursed into becoming a dog by a god he angered. However, after some mystical workings of hos own, he was able to regain some humanoid characteristics, such as the ability to speak and walk upright. Still, he usually pretends to be an ordinary dog, stating that "If you're just a really smart dog, you can still get things to go your way with a litte work. If you're a talking dog, people tend to want to cut you open to see what makes you tick." With Brain's help, Gadget finds out that he is in fact biologically dead, and upon death possessed the various electronic devices in Slickstein's lab and became a technology elemental (Swamp Thing Reference). All of his gadgets, including the Gadgetmobile (which is in actuality a normal car) are a result of his ability to manipulate an possess electronic devices. He subconsciously fabricated the memories of Slickstein creating his gadgets to cope with the whole ordeal. After learning all of this, Gadget simply says "...cool" and asks penny if she wants to order out for Chinese food for dinner.
Shortly thereafter, Gadget gets a partner in Adam DaFoe, a detective with severe memory problems an an expertese in unusual/suprnatural crimes. It is soon revealed that Adam is one of the oldest humans on Earth and just has a really really ****ty memory, so he keeps forgeting who he is every few decades (Powers reference).
Meanwhile, within MAD, Claw is challenged as leader by Phinease McGuffin, the smooth talking, manipulative head of one of MAD's corperate fronts who thinks he can run the show better. He ends up usurping Claw and leaving him for dead in the middle of a dessert.
Gadget has several cases with Adam, Penny, and Brain, dealing with all manner of unusual crime. One notable one is when they take on The Big G, a completely insane and nigh omnipotent entity who wishes to rewrite reality in a bizar, surrealistic fashion (reference to both Red Jack from Grant Morrison's Doom patrol and, more importantly, Grant Morrison himself).
Eventually, Claw is revealed to be (barely) surviving in the dessert, living as a hermit. All of this changes when Claw runs across the Nex, a child of two gods from rival pantheons with seemingly limtless power. Claw fuses with Nex and gains control of all of it's power (reference to Jesse Custer and Genesis). With his newfound power, Claw deems MAD to be beneath him, effortlessly destroys the entire organization within a matter of minutes, and moves on to bigger and better oportunities. He finds them in "The Big Guys," a group of super-gods, each one a direct personification of aspects of life and the human condition (reference to The Endless). Claw does battle with them, atempting to gain control of their dominions and remake the universe in his image. The only wrench in the system is Gadget. Big showdown between the two arch rivals to cap everything off. Fun stuff.
During the final battle, Claw knocks gadget into the wall of reality, causing a "Retcon Bump." The next thing we know, it's "One Year Later." This is followed by a twelve issue story arc entitled "Twelve," told in real time with each issue covering roughly a month. Twelve has various seemingly unconnected and unimportant sub plots revolving around all of the supporting characters, who all have been unnecesairily changed by the retcon bumb, some being much more like they were in the cartoon, forgeting aspects of their lives added or built upon by the comic for no reason. Gadget is missing for all of Twelve, and one of the sub plots is Penny searcjing for him.
Of course, this is just a rough outline. There would be filler stuff and storylines that aren't parodies, but I haven't thought of them yet.
Also, one note: While Gadget and most of the stories would be played for comedy, Claw would, at least as a character, be played completely straight. He'd be a ruthless criminal mastermind and a truely badass villain. There'd still be comedic bits with him in them, but he'd be the straight man.
