To answer the thread's question, sure. It doesn't have to happen, but I think it can be good if it does happen as long as they don't stick close to the comic.
The Clone Saga was a good story on paper that was horrendously executed. A properly-done Clone Saga has a lot of potential IMO. It was meh in Ultimate Spider-Man and although the 90's series' take was fantastic, it was more of an alternate-dimension saga with an alternate-universe Ben Reilly clone thrown in. TSSM was also building up the Clone Saga, but then it got cancelled. I know there is remake comic written by the original writers (which I hear is a huge improvement), but I never read it.