See, I could pick a few points where it could have ended (although, I think it should NEVER END).
1- Amazing Spider-Man #200
Come on....this is the best way to end Spider-Man!! He has to fight the burglar, while shot and powerless? AWESOME! And what a build-up! The ending was perfect.
2- Spider-Girl
Have us SEE the battle where Norman dies and Peter loses his leg, and then have Mayday take over. We still have a web-slinger, and we can still read about Peter....NOW IF PEOPLE WOULD HAVE QUIT BUYING ASM AND BOUGHT ASG, WE COULD STILL HAVE THAT!!!
*ahem*
3- Amazing Spider-Man# 350
Most of the Spider-Man stories I read after this really sucked. Maybe it was because Lrsen left, or maybe it was because every issue after that featured a million guest stars, symbiotes, or clones, but this was one of the last "fun" stories of the 90s.
4- One More Day
WHAT?!?! Hear me out....Spider-Man deosn't make the deal with Mephisto to save Aunt May, but instead gets Loki to help him, but it costs him his Spider-powers, and he never unmasked, leaving Peter and MJ to leave a normal life, happily ever after.