theinfernoman
That guy
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But it actually doesn't. I can go to the store and get a genetically modified watermelon right now. I will not become part watermelon. There are plenty of GM animals. If they bite me, no super powers.
There are, to this day, experiments being done using radiation to induce mutations. There was a study using flies that was pretty interesting. Radiation does have the ability to break ionic bonds and change DNA, therefor there's at least some logic there.
All you need is some creative techno-babble, like the Neogenic recombinator. Invent a machine that uses a principal similar to structural resonance frequencies in sound. Harmonic radiation fields are generated to mold a DNA molecule into a specific arrangement. It's not that hard.
All that doesn't matter when the amount of radiation in the spider would be too small to have any effect whatsoever. The thing about the spider being genetically modified is that we really have no idea what has been done to the spider, making it a lot more believable.