Spider-Man 4
Peter's life has hit some rough times. With his best friend slain and the aftermath of SM3 still looming over his head, Peter is questioning his actions and the reasons behind them.
When Dr. Connors transforms himself into the hideous Lizard, Spider-Man springs into action, using all of his strength in vain attempts to take this beast out. However, once he discovers his new nemesis's true identity, Peter makes the rash decision to protect the man who was once his mentor and helps Connors escape NYPD.
Once the Daily Bugle recieves photos of Spider-Man's actions, Jameson leaps at the chance to finally force the webslinger to hang up his webs for good. After issuing a reward for Spider-Man's capture, Spider-Man finds himself running from not only angered citizens and police, but from Electro, one of New York City's newest supervillains.
With the lives of Mary Jane and the entire city hanging in the balance, Spider-Man must learn to rise from the ashes of defeat and use past lessons to become the hero he was always meant to be. With Electro hot on his trail and with his struggle with the Lizard, Spider-Man must face his greatest battle yet.