I might compare Tobey's (Parker) to Tom Wellings recent Smallville, crisis on infinite earth, Cameo... (Wellings also took a break from acting after Smallville for a while, an even after starting back up, was always reluctant to return to the character for anything else, but finally made a return when he felt the right story came along)
but, I could see him being the Peter who retired and settled down with MJ, had kid(s) (I mean that's seem fitting for his character who always just wanted to give it up to be with MJ)
maybe ad a pilot twist, since it has been so long since we've seen them, perhaps his daughter Mayday, starts to develop into her own powers/figures out who her father was, an wants to take on the legacy (becoming Spider-Girl) and Peter reluctantly becomes her superhero mentor (believing that if he didn't help her, she would just go off and do it on her own, anyway and get hurt)