The Facebook layout really has no affect on my overall life.
But because it has become a staple in my daily routine, at first I was annoyed by it, because I had no idea what the creators were going for with this facelift. I couldn't find anything, the wall seemed to have disappeared on me... I was a bit distraught.
Then I realized how efficient it is, because I no longer have to scroll through ten thousand stupid applications to post something on someone's wall. In fact, I don't have to deal with any ridiculous applications, because they now have their own tab. I don't have to worry about feeling "unpopular" because I have a lower wall post count than others, as the counter has disappeared; I don't have to scroll through the page looking for a specific piece of information... this is a far more efficient improvement than previous changes.
So I am actually pleased with the new Facebook.