MOR3 SPID3Y QUIPS, PL3AS3!!!
Other than that, I would like time to be balanced according to the importance of each character. That is, less time for Sandman (probably using him mostly in the beginning just to show Spidey's job is never done would be best), Mary can all but dissapear with her budding career taking more of her time, more time to complete Harry's transition, a sizeable amount of the beautiful Gwen (but its not fair since she gets a late start for her to gobble up too much time), and a good amount of development time for Eddie Brock and then Venom, and most importanly, more Spider-Man (but with as many people he's going to have to face, I don't think there's much of a chance).
Spidey should staple his mask to his shoulders, btw. That might keep it from coming off this time.