The meta-story is centered around Deadpool kidnapping the employees of High Moon Studios and forcing them to make the most awesome game ever starring himself. The story of the game is set with Deadpool accepting a mission to assassinate Chance White, a corrupt media mogul whose television channel produces such quality programming as “
Jump the Shark”, in which celebrities must literally jump over a tank of water containing a ravenous great white shark. After
Mister Sinister botches Deadpool's mission, costing him money, Deadpool seeks revenge on him and tracks him to the former mutant haven,
Genosha, where Sinister is collecting new DNA to use in his armies.