I'm taking some of these rumors with a grain of salt. The motions I have seen from Marvel Animation lately is that Jeph Loeb wants to start and maintain his own era and that means stepping away from the old one. I mean, fairness aside, he's been hired as Marvel's TV czar which means his job is to influence their TV shows with his vision. If he just continued with the previous era was doing, anyone could do that. Loeb isn't just anyone, he's Jeph ****ing Loeb, Hollywood contact who wrote some really great things 15 years ago and ran an NBC show into the ground.
It reminds me of when Sony hemmed and hawed about whether "AMAZING SPIDER-MAN" was a reboot, a sequel, or a prequel to the Raimi films and they gave a lot of conflicting answers. In the end? Reboot. They just didn't want to say the wrong thing and get negative buzz.
I imagine some of the voice actors will return. Fred Tatasciore voiced Hulk in "ULTIMATE SPIDER-MAN" after all. That said, I'd imagine whoever voices Iron Man or Thor in "USM" will reprise for this show. And I am not buying whether this is a sequel to EMH until I see a teaser. I imagine it will have some similarities but I'm not expecting it to be.
Hopefully A:EMH season 2 will get on DVD soon. Kind of surprised that not even a soccer mom set of the first 7 episodes of that season has been announced yet.