Like Corp & Darth have said, BLUE BEETLE has remained mostly separated from the DC's events. It has tie-in's but they are self contained. The only quibble may be the beginning, as Jamie technically debuted in INFINITE CRISIS, not BLUE BEETLE, which recaps his story and embellishes the origin. I'm pretty certain you could read it and get all you need to know. The first trade deals heavily with his origin, after all. I hardly collect many DC titles either, and I completely enjoy the book.
I almost never dive headfirst into new books out of fear of not knowing the continuity. I recommend this. That says somethin'.