The setting of Lords of Shadow is during "the end of days". The Earth's alliance with the Heavens has been threatened by a malevolent force known as the Lords of Shadow. The souls of the deceased and evil creatures inhabit the dying land, and attack living people.
The main character, Gabriel, is a member of an elite group known as the "Brotherhood of Light". The group are holy knights who protect and defend innocent people against the supernatural. Gabriel's wife was brutally murdered by the evil creatures, and her soul has been "trapped for eternity". Because she is neither alive or dead, she realizes what is at stake and guides Gabriel to his destiny to save the world. He travels the destroyed land, defeating monsters in order to use their powers to bring balance back to the world. Armed with the versatile weapon, the "Combat Cross", he searches for the three factions of the Lords of Shadow to defeat them.