Introduing villains that have never been done before in animation is cool, but doing a whole show around them is a bad idea. According to the most recent article that posted in the other thread, this show isn't going to have the A listers in it. i.e. Joker, Riddler, etc.
Seeing as that is only a prototype, the design could change radically between now and when the show is in progress. If you had seen the original test footage for "The Batman" (the series just before Brave and the Bold). you would have seen the designs were way different than what they ended up with, they actually had less stylized designs than the show eventually did, and looked more like designs from the actual comics.
This design we see here may or may not end up as the final version, we'll have to wait and see.
From what I know so far it will be. Probably very similar to the Green Lantern animated series. I'm okay with them introducing some lesser known villains, but I also believe they eventually have to work in the big names as well. I think they can very well put more focus on new villains and give them some time to shine and in between those, have shows that bring in Joker, Riddler, Penguin, Mr. Freeze, etc. I will hold off judgement until I see more though I am excited with the potential.
I actually like that it's taking a more pulpy route like the earliest Batman comics. That hasn't really been done yet and those comics were great despite not having any of the A list rogues in them so I don't mind never seeing The Joker or Two-Face in this show to be honest.
If they go the route of using Hugo Strange and his Monster Men as well as Doctor Death and the Mad Monk in addition to Pyg and them this could be a stand out. I have faith in Murakami and his team.