here's the in depth idea i had:
3:
Green Goblin 2 fights Peter in the first 5 minutes (confirmed i think)
couple of battle with Sandman (comfirmed i think)
Spidey & GG2 vs. Sandman & Venom (comfirmed i think)
Venom kill Green Goblin 2 and Sandman. (comfirmed i think)
Venom is somehow weakened and escapes.
4:
Venom comes back and meets Peter in his apartment and sets the place on fire during a battle. the fire weakens Venom and he is captured by Police.
Connors turns into the Lizard and battles Spider-Man
Spider-Man knocks Lizard unconcious and police take him in, then they go to Spider-Man (thinking he's a criminal because of some of the things he does in SM3) and tells him get in the car or Connors will die. Spidey obeys and is sent to a high-security prison with electo-bars. He's placed in the cell with Lizard. and right across from them is Eddie and Cletus Kasady.
The symbiote finds Brock, spawns off Carnage and the two attache each other to the correct hosts. Spidey sees this and starts trying to break the bars. Connors wakes up and starts the "lizard process" Then there is a big battle between Venom, Carnage, Lizard, Spider-Man.
Spider-Man and Lizard are knocked unconscious. Carnage sucks Eddie's symbiote up in his own symbiote and therefor making himself more strong. Carnage kills Eddie.
Carnage goes on a killing spree.
Lizard is momentarily cured sometime later.
Spider-Man goes after Carnage and finally defeats him using the same bell-tower he used to get the Symbiote off of himself in SM3.
(The Peter-Plot could be the world finding out Peter Parker is Spider-Man or something.
)
5:
Spider-Man battles Electro
Spider-Man battles Vulture
Spider-Man captures Vulture and he is sent to jail.
Spider-Man vs. Hydro-Man vs. Electro
Electro could use his electricity to defeat Hydro-Man.
Spider-Man battles Electro and defeats him for the time being.
There could be signs of Connors turning back into Lizard.
6:
Spider-Man battles Scorpion
Spider-Man battles Lizard and finally cures him for good.
Spider-Man battles Electro
Spider-Man vs. Scorpion vs. Electro vs. Shocker
(even though now that i think about it, the Sinister Six idea would be better for #6... with the addition of Lizard to be a side villain for a short time.)