Are you even sure we're getting a Spider-Man 6? At least in the newar future? It seems they are wrapping up all loose ends in this movie and several key actors either flat out refuse to do a fourth (Dunst) or sound hesitant (Maguire) as does Raimi, and we ALL KNOW what happens when you switch directors. we're like "Oh sure, not gonna' be Schumaucher every time" but the A-directors aren't gonna' want to take the reins in a superhero franchise that another director has already created and led through several films....why do you think we ended up with Ratner ****ting on Singer's vision for X3?
I really, REALLY want to see the Lizard on the big screen, but it feels like this may be it and in 15-20 years someone else will restart or "vague history" a new Spider-Man movie (a restart could do the Gwen Stacy saga though....).