The Big Lebowski
Pretty much a comedic spin on a Raymond Chandler detective story. See also Brick.
You're probably looking at something like Being John Malcovich, Adaptation, and Synecdoche, New York for true originality.
But, originality isn't the be all and end all of storytelling. The point of fiction is to entertain and provide insight into the human condition. You don't necessarily need to be original to do that.