So, this Scarlet Witch series, here's my take, my musings and ideas;
I would set the series in New Salem and Wundagore.
New Salem enables world-building and also handily explains why other Avengers are not involved; they and Strange dont even know New Salem exists.
I think Feige wants a female relationship focused story, and I think the Scarlet Witch mini series will have a female dominated cast.
As such I think the relationship between Wanda and Agatha would be the main focus aside from Wanda herself.
Vertigo would fill the Kilmonger/Mordo role, representing the rejection of humanity. Salem's 7 would be elite Witches and Warlocks, rather than magical creatures. She would represent New Salem's isolationist ideology.
Agatha teaches Wanda the Witch's sight and this enables Wanda to recall her earliest memories, of birth on Mount Wundagore. No citadel of science, instead a hidden Chthonic temple containing Living Clay and covered in Everbloom.
Wundagore sees a return to Sokovia and Wanda being drawn to her birthplace, to Chthon.
Chthon being the patriarch to Agatha's matriarch, both training Wanda but with very different goals, would be a strong theme. Modred the Mystic being the tragic villain, a warning to Wanda of the danger that comes with the power of Chthon.
Wanda journeys into Chthon's dimension and confronts him, he mentions her lineage, and claims he decides her destiny. He offers to restore Vision's soul, tempting her. She refuses. Because he is part of her, he is unable to attack her as he would any other sorcerer.
She returns to New Salem and is granted the title of "Scarlet Witch" by Agatha and the witches, which Agatha reveals to be the title held by her great grandmother, Natalya.
Cast:
Scarlet Witch
Agatha Harkness
Chthon
Modred the Mystic
Vertigo
Gazelle
Vakume
Hydron
Reptilla
Thorn
Brutacus
Emerald Warlock
Kierok the Damned
N'garai
Ancient One (flashback, with Agatha)
Vision
Set
Gaea
Oshtur
Guest appearances: Shuri, Doctor Strange.