It starts out pretty much as seen in the preview... a mystery man fights another guy while the house is on fire several years ago in Portland... the mystery man looks like Peter Parker, so we could "assume" that it was Ben Reilly.
We then move to today in Boston where JJJSr. has flown everybody to a restaurent for a surprise for May, which turns out to be a Reilly family reunion headed by May's sister Jan. There's a mention of another sister April that is the black sheep of the family and nobody talks to her. We get to see Peter's newfound cousins, especially some "hot" ones that Peter can't help take his eyes off of... Meanwhile, the villain "Raptor" is watching this because he's been watching the Reilly family for 6 months, and he's pleased because the reunion has finally drawn "him" out...
When Peter ducks into the bathroom, Raptor attacks Peter, there's a minor scrimmage and Peter throws them both out the window (as he would if he didn't have powers and was just scared). Raptor crashes to the pavement only to find himself attacked by Spider-Man. There's a big fight all the while Raptor claims he's not the bad guy and he wants Spidey to back off. This goes on for a while until Spidey finally asks to the guy what he had against Peter Parker... to which the guy responds... "His name's not Peter Parker! His name is Ben Reilly!".
Naturally, hearing the name sends Spidey into a semi-state of shock as memories of the Clone Saga fill the next few pages with various pics of Ben and the Scarlet Spider. "Ben Reilly" he thinks... "A name I haven't heard in years. A name I thought I'd never hear again."...
Spidey then tells the guy Ben Reilly is dead, he flips out and calls Spidey a liar and escapes.
Though thanks to police reports, Spidey gets the name of his assailant... Damon Ryder.
When Peter gets back to NY, he googles the name, and it gives him the story about the fire in which Ryder's family died and he was the sole survivor.
It ends with Peter questioning to himself... "Ben... What did you do?"
Continued in Amazing Spider-Man!