^
That's a really good idea, but if they were doing a villain-centric series, I don't think it should just be a bad guy going after a worse bad guy and/or teaming up with a hero, since that would make him more of an anti-hero than a villain. Marvel already has enough of those (cue stylistically drawn skull image). The Taskmaster idea is a really good idea, though. Mine is a complete fan-wank, and dependent on Fox's upcoming Fantastic Four movie falling apart and the rights returning to Marvel. I know, a long-shot, but... *crosses fingers*
Doom: Rise Of Latveria
A single season that would span, maybe, fifteen years starting out with Victor graduating college and culminating in the present day with him installed as the dictator of the small Eastern European state of Latveria. Would not involve the Fantastic Four, but would merely allude to them, thus perfectly setting up a future Fantastic Four movie.