Daken is getting his own ongoing (Wolverine's getting his book back) and Moonstone has been revealed as being in the new Thunderbolts lineup led by Luke Cage. She's most likely getting arrested and forced to work for the government as a prisoner.
Osborn is either getting killed or going to jail, if I were a betting man I'd say killed, just because I'm getting that feeling from the solits of ASM: American Son limited series which is mostly about Harry Osborn in a post SIEGE Marvel U. He might actually become American Son since it's what his dad wanted, it sounds wacky but the Osborn's are wacky.
I'm praying Sentry gets killed, but going to space with Nova and Guardians of the Galaxy may save the character.
Bullseye is getting killed as far as I'm concerned. I think you can take that to the bank. He's got no reason to go back to DD since they have Lady Bullseye in that book and she's more of a fresh character.
Venom-Gargan will either die or fade into obscurity.
That leaves Victoria Hand, who really isn't a villain, she's just a disgraced SHIELD agent that Osborn picked out of a hat to be his assistant. I'd like to see her join up with the Avengers or Secret Avengers in some capacity.