I just figured their love would be so powerful, she'd break the spell lol. I really don't need the multiverse contrivances to get Zendaya back in the game.
Everyone else only remembers Spider-Man...not Peter Parker (we don't really need to get into the specificities of who remembers what & how). So, outside of Zendaya's MJ, Peter can have a brand new supporting cast--Donald Glover's Aaron Davis, Miles Morales, the street-level defenders (Daredevil, Punisher, Kate Bishop Hawkeye, Echo, etc.). I've even pitched Betty Brant as Spidey's contact at the New York Bulletin (no way she'd stay working with J Jonah Jameson in this universe). Give us Jean DeWolff and Felicia Hardy
There's so many additional supporting characters that the Holland Spider-Man can meet/interact with so he doesn't need to be chasing Ned Leeds around anymore. It worked for an origin trilogy, but lets move forward here...
And moving beyond supporting characters, there's so many villains we can tap into--Wilson Fisk / Kingpin, Scorpion, Prowler, the Enforcers, Silver Sable and the Wild Pack, Alistair Smythe & the Spider Slayers, Mister Negative, Tombstone, Hammerhead, Silvermane--many street-level, yes, but plenty of opportunity for big & explosive action set pieces.