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The Scientific Discovery Thread: Blow Our Minds World!

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New "Senolytic" Drugs Can Dramatically Increase Healthy Lifespan

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Researchers from the Scripps Research Institute and the Mayo Clinic have developed a new class of drugs that were shown to significantly slow the aging process in animal models. Remarkably, dramatic improvements were noticeable just days after treatment.

The research was only carried out on mice, but the introduction of an entirely new class of drugs, called "senolytics," could have incredible potential for humans as well.

"We view this study as a big, first step toward developing treatments that can be given safely to patients to extend healthspan or to treat age-related diseases and disorders," noted Scripps lead researcher Paul Robbins in a statement. "When senolytic agents, like the combination we identified, are used clinically, the results could be transformative."

Working with the prototype drugs, the researchers documented how they can be used to delay, prevent, alleviate, or even reverse a number of chronic age-related diseases and disabilities as a group, rather than concentrating on one at a time. In this sense, it's truly an "anti-aging" intervention.

The drugs work by selectively targeting and killing senescent cells — older cells that have stopped dividing but are steadily accumulating and contributing to the aging process.

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To make it work, the researchers combined dasatinib (a cancer drug also known as Sprycel), and quercetin, a natural compound sold as a supplement that works as an antihistamine and anti-inflammatory. Together, these compounds induced the death of problematic cells. In cell samples, dasatinib was shown to eliminate senescent human fat cell progenitors, while quercetin proved its worth against senescent endothelial and mouse bone marrow stem cells. But it was as a cocktail that the new drugs were the most effective.

The researchers found that, among older mice, cardiovascular function improved a mere five days after a single dose of the drugs. A single dose of the cocktail also improved the exercise capacity of mice weakened by radiation therapy used for cancer, and the effect lasted for at least seven months following treatment. Aged mice given periodic treatments also displayed improvements to various age-related symptoms, including spine degeneration, and osteoporosis.

Not surprisingly, both drugs have the potential to introduce side-effects, particularly with long-term treatment. Much more testing is needed before human trails can begin. That said, the researchers are optimistic that senolytic treatments to clear damaged cells will be infrequent, thus reducing the chances of side-effects.

http://onlinelibrary.wiley.com/doi/10.1111/acel.12344/abstract

That's freaking awesome
 
The Ancient Secrets of a "Bleeding" Glacier Are Finally Being Revealed

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Against vast whiteness of Antarctica, Blood Falls bleeds a deep dramatic red. The color comes from iron-rich ancient seawater trapped under the ice for 2 million years. For the first time, scientists have been able to take a sample from deep under the ice.

The five-story tall Blood Falls was first discovered in 1911. In 2004, a team including Jill Mikucki, a microbiologist now at the University of Tennessee Knoxville, sampled the microbial life at the mouth of the falls. Because the microbes oozing out normally live in dark, oxygen-less, and extremely salt places, Blood Falls is a unique place to study extremophiles outside of their inaccessible natural habitat.

Mikucki went on to publish her work in Science, but there was still a problem. Exposure to the light and oxygen at the mouth of the falls could skew the results. This winter (or summer in Antarctica), she returned with a team and the IceMole, which the Antarctic Sun describes:

The IceMole is a long rectangular metal box with a copper head and ice screw at one end capable of melting its way through ice – but not just straight down like a conventional electro-thermal drill. Differential heating at the tip allows IceMole to change directions. It looks a bit like a very large hypodermic needle poised to inoculate a glacier.​

Using the IceMole, Mikucki's team directly sampled a major vein that leads from the buried brine reservoir to the falls. (The reservoir itself is even further up the glacier and buried below even more ice, making it a considerable challenge.) To locate the liquid veins and guide the IceMole, the team used thermometers placed in boreholes in the ice.

The team will be analyzing these new, uncontaminated samples for chemical content and microbial life. Blood Falls is pretty much unlike any other place on Earth, so the extremophiles that live in it, isolated for millions of years, are likely to be pretty unique, too.

http://antarcticsun.usap.gov/science/contentHandler.cfm?id=4122

Very cool :o
 
A New Kind of Brain Stimulation that Uses Magnets and ... Spice

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Deep brain stimulation involves threading electrodes deep into the brain — it's invasive, but it's also an effective way to treat disorders like Parkinson's and depression. But now scientists have a new wireless brain stimulation technique, which targets the proteins that sense heat and spice.

New Scientist reports on a study in Science, where researchers injected tiny nanoparticles of metal deep into the brains of mice. When a magnetic field that continuously switches direction is applied to these nanoparticles, they give off heat—a well-known effect that has been used to kill off cancerous cells.

Polina Anikeeva, now at MIT, wanted to see it this could work in the brain, not to damage neurons but to give them a gentle nudge. Neurons have TRPV1 receptors, essentially proteins that sense heat. Could the heat from the nanoparticles activate nearby neurons? Indeed, experiments in three mice found applying a magnetic field to the nanoparticles made neurons fire.

As with all mice studies, this is still a long way from being a treatment in humans. Human brains contain more TRPV1 receptors, for example, so targeting select neurons may be more difficult. But if it does work, this technique could be a slightly less invasive and wireless way to carry out deep brain stimulation.

http://www.newscientist.com/article/dn27158-vibrating-magnetic-balls-stimulate-brain-wirelessly.html

Awesome
 
Scientists Have Just Invented Synthetic Chameleon Skin

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It's been a big week for chameleons. On Tuesday, scientists announced they'd worked out the secret to the cross-eyed lizard's color changing skin. A day later came the announcement that we'd replicated the skin artificially.

Chameleons are among the select few organisms that are able to change their color at will. There are many different reasons color-changing has evolved in nature, from camouflage to predation to attracting a mate. But most rely on a similar principle: Tuning nanoscale structures to bend and reflect light in different ways.

The chameleon's color-changing trick is actually quite simple. A layer of skin cells contains nanocrystals which reflect light at wavelengths related to their spacing. When the chameleon's skin is relaxed, it takes on one color. When it stretches, the nanocrystals spread out—andthe color changes. That discovery was reported earlier this week in Nature Communications.

Now a synthetic color changing material—described this week the journal Optica—takes a page from the chameleon's book, using nanoscale structural features to reflect select colors of light. Basically, tiny rows of ridges are etched onto a silicon film a thousand times thinner than a human hair. Each of these ridges reflects a very specific wavelength of light. By altering the spacing between the ridges, it's possible to finely tune the wavelength of light reflected. That means, like chameleon skin, this material's color changes when stretched.

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http://www.osa.org/en-us/about_osa/...eers_create_chameleon-like_artificial_‘skin’/

Very cool
 
Japanese Scientists Just Beamed Energy Through the Air

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Human-made satellites have long been able to harness the sun's energy as it washes over them outside the protection of our atmosphere. But what if we could beam all that solar power down to Earth? The science fictional idea may be a reality sooner than you think.

That's because Japanese scientists have just made a critical breakthrough in wireless energy transmission. According to Phys.Org, researchers used microwaves to deliver 1.8 kilowatts of power through the air to a receiver 170 feet away. While the distance is not huge, the achievement is being hailed as a critical step toward the development of space-based solar collectors that beam energy back to Earth's surface.

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The Japan Aerospace Exploration Agency (JAXA) has been working on the problem of space-based solar powered collectors for years. JAXA hopes to one day fill the sky with solar farms that can soak up the sun's energy, regardless of the weather conditions, and zap it back to us in the form of microwave radiation. We're still years out from such technology existing, but if we're ever going to seriously reduce our dependency on fossil fuels, doubling down on the sun is probably one of the best options we've got.

http://phys.org/news/2015-03-japan-space-scientists-wireless-energy.html

Damn, that's big news
 
A fully transparent solar cell that could make every window and screen a power source

http://www.extremetech.com/extreme/...d-screen-a-power-source#.VQCE8_qHJ3o.facebook

My friend shared this. I hope they feature stuff like this in Tomorrowland!
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Researchers at Michigan State University have created a fully transparent solar concentrator, which could turn any window or sheet of glass (like your smartphone’s screen) into a photovoltaic solar cell. Unlike other “transparent” solar cells that we’ve reported on in the past, this one really is transparent, as you can see in the photos throughout this story. According to Richard Lunt, who led the research, the team are confident that the transparent solar panels can be efficiently deployed in a wide range of settings, from “tall buildings with lots of windows or any kind of mobile device that demands high aesthetic quality like a phone or e-reader.”
Scientifically, a transparent solar panel is something of an oxymoron. Solar cells, specifically the photovoltaic kind, make energy by absorbing photons (sunlight) and converting them into electrons (electricity). If a material is transparent, however, by definition it means that all of the light passes through the medium to strike the back of your eye. This is why previous transparent solar cells have actually only been partially transparent — and, to add insult to injury, they usually they cast a colorful shadow too.

To get around this limitation, the Michigan State researchers use a slightly different technique for gathering sunlight. Instead of trying to create a transparent photovoltaic cell (which is nigh impossible), they use a transparent luminescent solar concentrator (TLSC). The TLSC consists of organic salts that absorb specific non-visible wavelengths of ultraviolet and infrared light, which they then luminesce (glow) as another wavelength of infrared light (also non-visible). This emitted infrared light is guided to the edge of plastic, where thin strips of conventional photovoltaic solar cell convert it into electricity. [Research paper: DOI: 10.1002/adom.201400103 - "Near-Infrared Harvesting Transparent Luminescent Solar Concentrators"]
If you look closely, you can see a couple of black strips along the edges of plastic block. Otherwise, though, the active organic material — and thus the bulk of the solar panel — is highly transparent. (Read: Solar singlet fission bends the laws of physics to boost solar power efficiency by 30%.)
Michigan’s TLSC currently has an efficiency of around 1%, but they think 5% should be possible. Non-transparent luminescent concentrators (which bathe the room in colorful light) max out at around 7%. On their own these aren’t huge figures, but on a larger scale — every window in a house or office block — the numbers quickly add up. Likewise, while we’re probably not talking about a technology that can keep your smartphone or tablet running indefinitely, replacing your device’s display with a TLSC could net you a few more minutes or hours of usage on a single battery charge.
The researchers are confident that the technology can be scaled all the way from large industrial and commercial applications, down to consumer devices, while remaining “affordable.” So far, one of the larger barriers to large-scale adoption of solar power is the intrusive and ugly nature of solar panels — obviously, if we can produce large amounts of solar power from sheets of glass and plastic that look like normal sheets of glass and plastic, then that would be big.
A fully transparent solar cell that could make every window and screen a power source



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A New Synthetic Compound Can Neutralize Chemical Weapons in Minutes

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Chemical weapons are a dangerous and all-to-real threat. Now, a team of scientists has developed a new compound that can deactivate chemical weapons—including nerve agents like sarin—in just minutes.

A team from Northwestern University in Evanston, Illinois, have found inspiration for the new compound in enzymes called phosphotriesterases. Usually produced by bacteria, these proteins deactivate some pesticides—and nerves gases—in milliseconds. Problem is, those enzymes can break down easily, losing their ability to halt the actions of the dangerous compounds.

So the researchers attempted to reproduce the same effects using a synthetic catalyst. Science describes nicely how they went about the process:

They started with metal-organic frameworks (MOFs), a recently developed class of porous compounds composed of metals arranged in a crystalline network linked by carbon-based molecules. MOFs are highly adaptable materials... and because MOFs are porous, they have large surface areas that can rapidly create chemical bonds, making them good candidates for catalysts.

In the natural enzyme, phosphotriesterase, two zinc atoms act as so-called Lewis acids, which accept electrons to bind with the nerve agent. Once the agent has bonded, hydrolysis occurs—a water molecule attacks the agent, slicing and dicing essential chemical bonds, thereby deactivating it. The scientists designed a MOF with a similar structure, but they replaced the zinc with zirconium, which likewise behaves as a Lewis acid and makes for an ultrastable MOF.​

In tests published in Nature Materials, the team used their catalyst to deactivate a pesticide similar to nerve agents but safer to use in the lab. Experiments showed that the new compounds—known as NU-1000—deactivated half of the pesticide in 15 minutes. Further testing by U.S army facilities has shown that it neutralizes half of the nerve agent GD—more toxic than the well-known sarin—in just three minutes. The researchers claim that that's 80 times faster than any previous compound has managed.


It's still not perfect, though. Indeed, the natural version—though fragile—works up to 100,000 times faster, so the team certainly has some way to go before it's as good as nature itself. But for now, it's a significant milestone in the quest to keep the world safe from chemical warfare.

http://news.sciencemag.org/chemistry/2015/03/new-compound-quickly-disables-chemical-weapons

That's huge news
 
Researchers Turn Packing Peanuts Into Rechargeable Batteries

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Many of us have shared the guilty twinge of pouring a box of packing peanuts into a trash bag, knowing that our convenient foam waste will end up sitting in a landfill for the next few thousand years. Soon, however, we may be able to juice these little nuts for energy.

That's because chemical engineers Vilas Pol and Vinodkumar Etacheri of Purdue University have just developed a method to turn foam peanuts into components for rechargeable batteries. Like the rest of us, Pol felt guilty about tossing foam nuts whenever his lab received new equipment. He decided to do something about it, and with Etacheri's assistance, devised a way to turn peanuts into carbon microsheets and nanoparticles that can serve as anodes in lithium ion batteries. According to Pol, the new anode outperforms graphite-based anodes currently on the market, with 15 percent higher electrical storage capacity.

A video explains how Pol and his research team are turning packing peanuts into rechargeable battery components:

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Made from polystyrene—the same poorly degradable material found in Styrofoam—only about 10 percent of packing peanuts made in the United States are recycled today. According to Pol, both traditional packing peanuts and newer, "environmentally friendly" alternatives can pose risks:

"Outside in a landfill, potentially harmful substances in the peanuts, such as heavy metals, chlorides and phthalates, can easily leach into the environment and deteriorate soil and water quality. The starch-based alternatives also contain chemicals and detergents that can contaminate ecosystems," he said.​

Pol is optimistic that his new process could be scaled up and says that foam-based carbon microsheets and nanoparticles may be ready for commercial use within two years. He's also working on applying the method to the more-degradable starch based nuts. So hold onto those little foam nuts for now—soon, they may find a new home in all your favorite devices.

http://gizmodo.com/researchers-turn-packing-peanuts-into-rechargeable-batt-1692655199

Awesome way to turn a negative into a positive
 
Study Suggests Magnetic Fields Can Control Heat And Sound

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More than a hundred years ago, physicists discovered that heat is simply the energy stored in the vibrations of atoms. This meant that heat and sound are related. Now, for the first time ever, scientists have experimentally shown that these atomic vibrations have magnetic properties, too.

Sound is carried by periodic vibrations of atoms in gases, liquids and solids. When we talk to each other, the vocal chords of the speaker vibrate, causing the air coming from his lungs to vibrate as well. This creates sound waves, which then propagate through the air until they hit a listener's eardrums and make them vibrate as well. From these vibrations, the listener can then reconstruct the speaker's words.

Sound is affected by the surroundings in which it travels and by the frequency of the sound waves. We design musical instruments to manipulate the sound waves they produce. Further, we know that there are sound waves that are outside the range of human hearing, such as those produced by a dog whistle. As physicists have researched sound both inside and outside the range of human hearing, interesting properties have been discovered.

Building Our Knowledge of Sound

In the 1930s, physicists started modeling atomic vibrations as particles. This is similar to the concept of light as both a wave and a particle we call a photon. Physicists called the sound wave particles "phonons," derived from the Greek word for sound.

Today, physicists treat phonons as quasi-particles, having both wave and particle properties. Phonons carry both sound and heat. In metals, heat is carried primarily by the movement of electrons in the atoms. However, in all other materials, heat is carried almost exclusively by the phonons.

So the mechanical, acoustic and thermal properties of sound waves have long been established. Yet, before now, nobody ever imagined that sound waves might also have magnetic properties.

Heat, Sound… and Magnetism?

In the March 23 issue of Nature Materials, we offer experimental proof that sound waves do interact with external magnetic fields.

The experiment was carried out on a large, single crystal of a very pure semiconductor, indium antimonide, which had been cut into two unequal sections and then cooled to about -445F (-265C). A controlled amount of heat was made to flow in each section separately. At these temperatures, the phonons can be thought of as individual particles, like runners on a racetrack each carrying a little bucket of heat.

In the small section, the phonons often run into the walls, which slows them down. The small section is used as a reference, to make the experiment independent of the other properties of the solid that might interfere. In the large section, the phonons can go faster, and they don't run into the walls as much as into each other. When we apply a magnetic field, they tend to run into each other more frequently. Because the magnetic field increases the number of collisions, it also slows the phonons down and lowers the amount of heat they carry by 12%.

We think this is due to the electrons that rotate in orbits around each atom in the solid. The orbital motion of these electrons emits a very small intrinsic magnetic field that interacts with the externally applied field – an effect called "diamagnetism." This property exists even in substances we don't traditionally think of as magnetic, such as glass, stone or plastic. When the atoms vibrate due to the passing of the phonons, this interaction creates a force on the atoms that makes the phonons collide with each other more often.

What Can We Do With These Results

At this point, we've just described a new concept, something that had never been thought of before. Engineers can perhaps use this concept to control heat and sound waves magnetically. Sound waves can be effectively steered already by using multiple sources of sound, as is done in ultrasound imaging systems, but controlling heat conduction is much harder.

Conversion of heat into electrical or mechanical power, as is done in engines and in power stations, supplies over 90% of the energy humanity uses. Therefore, being able to control heat conduction at will could have an enormous impact on energy production, though, obviously, applications of this emergent concept are still quite a way in the future.

http://io9.com/study-suggests-magnetic-fields-can-control-heat-and-sou-1693561917

Very cool concept that could have a big impact on the world
 
Iceland Has Become the Perfect Genetics Experiment

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A millenium ago, a group settled in Iceland and have stayed there ever since, with few people coming and going. And so their DNA has stayed remarkably homogenous. That's a major boon for genetics researchers, who today have released the results of sequencing the complete genomes of 2,636 Icelanders—the largest such countrywide project ever.

Researchers at Decode Genetics, an Icelandic company owned by Amgen, have sifted through the complete DNA sequences of 2,636 people huntings for mutations that cause disease. This is a massive undertaking, but one made easier by the low level of genetic diversity in Iceland. With fewer genetic variants to sift through, it's easier to find meaningful variants.

Think of it as a smaller haystack in which to look for needles.

The results are published today in four papers in Nature Genetics. The researchers, who also had access to the medical histories of the participants, were able to identify several new mutations linked to disease. For example, notes Carl Zimmer reporting for the New York Times, a mutation in MYL4 caused early onset of a particular type of irregular heartbeat. And there's more:

The scientists also found a rare mutation to a gene called ABDB4 that raises the risk of gallstones. And they identified a gene called ABCA7 as a risk factor for Alzheimer's disease. Previous studies had suggested a gene in the genetic neighborhood of ABCA7 was associated with the disease. But the Icelandic study pinpointed the gene itself — and even the specific mutation involved.​

The study also identified "human knockouts," or people who have a nonfunctional copy of a particular gene. Scientists are especially interested in studying these people to figure out how a nonfunctional gene affects them. There's still, hopefully, many more insights to come from the this volcanic island in the north.

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3247.html

The human genome is such an amazing thing
 
A Re-Introduced Bill May Unlock Published Scientific Knowledge

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Promising public access legislation FASTR (Fair Access to Science & Technology Research Act) has been re-introduced by a bipartisan coalition in Congress. Lawmakers now have an important opportunity to strengthen and expand rules that allow taxpayers to freely read articles resulting from research their tax dollars support. EFF continues to encourage legislators to pass this bill as an important step forward—though there are still some measures to improve.

Shortly after FASTR was initially introduced in 2013, the White House released a directive requiring the results of research funded by major federal government entities to be made freely available to the public. In the two years since, eight agencies and departments have begun complying with that directive by releasing plans for putting research online.

Those steps have been successful and effective, and make a strong case for FASTR. The White House Directive is good, but codifying it through Congressional legislation would create a more stable rule, guaranteeing that the public's access is placed beyond the reach of any future presidential administration with different priorities.

Further, FASTR would strengthen the public access provisions in the Directive by reducing the embargo period—the length of time after research is published before it must be made freely available to the public—from 12 months down to six.

One major drawback of both the White House Directive and the FASTR legislation is the lack of an open licensing requirement. Public access is an important first step, but without open licensing, valuable secondary uses—like data mining, major cross-discipline analysis projects, and redistribution efforts—could be caught under a cloud of copyright uncertainty. In order to make the upgrade from "public access" to real "Open Access," future rules should include a requirement for the products of research to be released under a free license, like the Creative Commons Attribution (CC BY) license EFF uses for its publications.

FASTR's reintroduction comes at an exciting time for the open access movement: the movement has now been building steam for over a decade, and has chalked up some major successes. Also last week, the Wikimedia Foundation released a thorough Open Access policy that sets a strong example for non-governmental organizations. Under that policy, the results of research that Wikimedia supports through grants or collaboration must be released under a free license.

Take action to support FASTR right now and tell your lawmakers to support it today.

http://gizmodo.com/a-re-introduced-bill-may-unlock-published-scientific-kn-1693771843

Sounds like a good idea to me
 
Tiny 'Nanoneedles' Could Help Your Damaged Organs Repair Themselves

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In a trial involving mice, an international team of researchers used microscopic "nanoneedles" to coax the body into generating new blood vessels. Applied to humans, the technology could eventually be used to get organs and nerves to repair themselves.

Researchers from Imperial College London and the Houston Methodist Research Institute used the nanoneedles to deliver nucleic acids — the building blocks of all living organisms and transmitters of genetic information —to a specified area. Once delivered to a cell or tissue, the nucleic acids do their work by regenerating lost function. The researchers, a team led by Ciro Chiappini and Molly Stevens from the Imperial College London, describe their findings in the latest issue of Nature Materials.

In the case of the current study, DNA and siRNA nucleic acids were successfully delivered to human cells in the lab. Also, the researchers were able to facilitate a six-fold increase in the formation of new blood vessels in the back muscles of mice. The technique, conducted over a two-week period, didn't cause any inflammation or other harmful side effects.

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Acting like sponges, the porous nanoneedles — which are 1,000 times smaller than a human hair — can pack considerably more nucleic acids than solid structures. They work by bypassing the outer membrane of a cell, piercing it to deliver the nucleic acids. Notably, it does so without harming or killing the cell. By accessing a cell's cytoplasm directly, the researchers were able to efficiently reprogram it.

And because the nanoneedles are made from biodegradable silicon, they can be left in the body and not leave a toxic residue; they dissolve in about two days, leaving a negligible trace of harmless orthosilicic acid.

The nanoneedles have not been tested on humans, but the work on mice looks promising. Eventually, they could be used to restore lost function in tissues and organs, or used during organ transplants for an added boost as the organs settle into their new environment.

Conceivably, they could also be incorporated into a flexible bandage. For example, when applied to severely burnt skin they could reprogram the cells to heal the injury with functional tissue instead of forming a scar.

http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat4249.html

That is amazing
 
Scientists Just Broke a Quantum Record By Entangling 3,000 Atoms

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Quantum entanglement is an odd phenomenon that can connect two or more particles over even vast distances. Scientists have now managed to entangle not two, not 100 (the previous record), but 3,000 atoms with a single photon, opening the door to atomic clocks more accurate than ever.

In quantum entanglement, particles are correlated so that a change in one will instantaneously induce a change in others—even if they are at opposite ends of the universe. The classic example is a pair of entangled particles: If one changes its spin to clockwise, the other simultaneously flips to counterclockwise.

Entangling particles, especially large numbers of them, is no easy task. MIT and University of Belgrade scientists report in Nature that they managed to entangle 3,000 particles trapped in a supercooled cloud. The key was using very weak light, as weak as a single photon of light, which is less likely to disturb the cloud than a strong beam. The photon bounced thousands of times between two mirrors, passing back and forth through the cloud of atoms. This was enough to entangle the atoms, which LiveScience explains:

If a photon in a pulse interacted with the cloud’s atoms, the polarization of the photon would rotate slightly. Strangely, in the realm of quantum physics, the act of measurement can dramatically influence the object getting measured, and the act of detecting a photon that interacted with these atoms can essentially generate entanglement between those atoms.​

So why does this matter? One possible application is quantum clocks—the more atoms are entangled, the more accurate the clock. This technique might even be used to get around the uncertainty of quantum measurements. (Physics World has a great technical explanation of how.) Atomic clocks are used to keep track of GPS systems.

This could also be a step toward complex entangled states that can give us quantum computing and quantum encryption. But it’s also just pretty damn cool to push the limits of what’s possible.

http://www.livescience.com/50280-record-3000-atoms-entangled.html

This is very cool but quantum physics has always confused me a bit. It's just hard to wrap my head around how small it is
 
Every time I read this thread I feel like we are ever so close to some sort of revolutionary scientific discovery that will genuinely change our lives.
 
I hear ya man, I freaking love science and it seems like almost everyday something new and amazing gets reported.
 
New Fossil Dating Technique Casts Doubt On Human Origins

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A new dating technique has revised the estimated age of Little Foot from 2.2 million to 3.6 million years ago. That’s significant because it places the rare Australopithecus fossil within the same evolutionary timeframe as Lucy, a hominid from a separate species. Meaning humans may not be related to Lucy after all.

The nearly-complete skeletal remains of Little Foot, an ancient female hominid named after its four small foot bones, were uncovered in South Africa’s Sterkfontein Cave over 20 years ago. Scientists have been debating the age of the Australopithecus fossil ever since, with consensus settling around the 2.2 million year mark.

But now, a sophisticated new dating technique, called isochron burial dating, suggests the fossil is 3.67 million years old — give or take an incredibly small margin of 160,000 years. By using radioisotopes within the rock samples covering the remains, the scientists were able to accurately date when the rocks and the fossil were first buried.

The analysis of the 11 rock samples found near the site where Little Foot was found was conducted by a team of Purdue University and Wits University scientists headed by Darryl Granger, Kathy Kuman, and Ronald Clarke. Their results now appear in Nature.

The study indicates that Little Foot, a member of the species Australopithecus prometheus, lived at roughly the same time as Australopithecus afarensis — the species made famous by the Lucy fossil, which was found in Ethiopia. The new date of Little Foot suggests that A. afarensis was not the only hominid species that could have given rise to the Homo genus, the genus that we ourselves belong to.

“It demonstrates that the later hominids, for example, Australopithecus africanus and Paranthropus did not all have to have derived from Australopithecus afarensis,” said Clarke via this statement. “We have only a small number of sites and we tend to base our evolutionary scenarios on the few fossils we have from those sites.”

And as he told Reuters: “The fact, therefore, that we have at least two (Australopithecus) species living at the same time in different parts of Africa, (about) 3.67 million years ago, raises the question of how many other species there may have been which have not yet been discovered.”

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14268.html

That's what I love about science, we constantly are always trying to better understand the world and use new means to bring to light things that were unclear
 
A Magnetic Brain Implant Lets Blind Rats See Without Seeing

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A new brain implant doesn’t restore sight in blind rats, but it does something a whole lot weirder: give the rat the extra sense of geomagnetism. It could one day be a new way to navigate for blind people–or heck, even healthy people hankering for a sixth sense.

In the study published in Current Biology, scientists in Japan put a chip that could sense north and south inside the brains of rats. The rats also got two electrodes implanted in the visual cortex of the brains. If its head faced roughly north, the electrodes stimulated the right visual cortex. If south, then the left visual cortex.

Essentially, the rat can “see” which direction it’s facing without really, erh, seeing anything through its eyes. It was probably disorientating at first, but after two days and 60 trials, the blind rats could navigate a maze just as well as rats with sight. With the implants removed, they were lost again.

The experiment demonstrates yet again that the brain is remarkably plastic, and neuroscientists have experimented with mixing and matching sensory signals before. For example, a different brain implant let mice “touch” light.

“I’m dreaming that humans can expand their senses through artificial sensors for geomagnetism, ultraviolet, radio waves, ultrasonic waves and so on,” Yuji Ikegaya, the senior author study, told New Scientist. And it’s not a totally crazy idea, at least for people already convinced they want to explore sensory unknowns. People have implanted magnets in their fingers, and one guy hacked his hearing aids to hear Wi-Fi. Brains implants, though, would be a huge and invasive step up from these small tweaks.

http://www.newscientist.com/article...RSS|NSNS|2012-GLOBAL|online-news#.VR1uG5PF_vI

So basically Daredevil rats?
 
Kind of mean to make them see and then take the implants away. :(
 
Would you pay $9 for a lab-grown burger?

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Remember back in 2013 when that lab-grown burger was rolled out for a taste test? One big problem with the patty was that it cost roughly $385,000 to make. The scientist behind that lab burger says he can get the price down substantially.

Mark Post, a biologist at the University of Maastricht in the Netherlands, recently told ABC Australia that after tinkering with the process of making the schmeat, it could be produced for about $80 per kilogram.

Since the interview was in Australia I'm assuming the price is in Australian dollars and therefore the price in U.S. dollars would be about $9 for a five ounce patty (the size of the patty rolled out in 2013). If the price quotes was in U.S. dollars it works out to a little over $11. Either way, that's still a bit expensive but a lot more competitive than $385,000.

The real question of course is whether they can make it a tasty burger.

http://observationdeck.io9.com/would-you-pay-9-for-a-lab-grown-burger-1695497614/+riamisra

Something tells me lab grown meat is going to take off in the future
 
Newly Developed Liquid Perfume Starts To Smell Good When You Sweat

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Antiperspirants reduce perspiration and deodorants conceal its associated smells, but a new perfume developed by researchers at Queen's University Belfast uses sweat to its advantage, releasing pleasant aromas when it comes into contact with moisture and trapping molecules responsible for BO.

The researchers call their creation a "pro-fragrance ionic liquid with stable hemiacetal motifs." It sounds complicated, but it's pretty straightforward, conceptually. "Ionic liquid" is the fancy name for a salt that exists in a liquid state, in this case at around room temperature. When a fragrant alcohol is added to the liquid, the two form a hemiacetal. In the hemiacetal state, the compound is actually odorless. But when the compound is exposed to water (say, the moisture in your perspiration), a hydrogen molecule takes the place of the fragrant alcohol, freeing up the latter to do its job, i.e. smell good. Researchers H.Q. Nimal Gunaratne, Peter Nockemann, and Kenneth Seddon, all of Queen's University Ionic Liquid Laboratories (QUILL), describe their creation in greater detail in the journal Chemical Communications, but this figure summarizes things nicely:

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As an added benefit, the ionic liquid attracts thiols, the compounds in sweat responsible for its odor. So this "perfume release system," as the researchers call it, is actually working double duty, releasing pleasant smells and trapping bad ones simultaneously.

According to a press release from University Belfast, the researchers are looking to tap into the personal care industry and are working with a "perfume development company," which isn't exactly surprising. But Gunaratne says he thinks the system "could also be used in others area of science, such as the slow release of certain substances of interest." Therapeutic substances, perhaps? (What do you call the disease where rainbows erupt from your armpits every time you lift your hands over your head?)

http://io9.com/newly-developed-liquid-perfume-starts-to-smell-good-whe-1695502685

Now that is science put to good use
 
A New Way of Using Sound Waves to Find Rare Cancer Cells

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The cancer cells that circulate in many patients’ bloodstreams are incredibly rare but potentially dangerous. They break off from existing tumors, traveling to new locations where they can grow into new tumors. Scientists have come up with a better way of looking for these cells—using invisible sound waves.

Existing ways to sort cancer cells out of blood are slow, and they can damage cells, rendering them useless for further tests. Sound waves, however, can gently nudge healthy and cancerous cells apart. Here’s how it works, as explained by MIT’s news office.

The researchers built microfluidic devices with two acoustic transducers, which produce sound waves, on either side of a microchannel. When the two waves meet, they combine to form a standing wave (a wave that remains in constant position). This wave produces pressure nodes, or lines of low pressure. Because the sound waves are tilted so they run across the microchannel at an angle, each cell encounters several pressure nodes as it flows through the channel. As cells encounter each node, they are pushed further to the side of the channel; the distance of cell movement depends on their size and other properties, such as compressibility.​

The device, described in a recent issue of the journal PNAS, is 20 times faster than the prototype the team unveiled last year. The researchers used it to sort cancerous cells from the blood samples of three breast cancer patients. The key breakthrough with this technique is how it keeps the cancerous cells intact, so that they be isolated and studied in more detail. No more hiding in the haystack for these cells.

http://newsoffice.mit.edu/2015/sound-waves-detect-rare-cancer-cells-0406

Using sound to fight cancer, how do they even come up with this stuff? It's genius
 
NASA's Awesomely Elaborate Plan to Deal with Splattered Bug Guts

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Bug guts on your windshield are an inevitable part of life and a reminder of your own fleeting mortality. But they’re also a major drag on the aerodynamics of a car or plane—reducing the fuel efficiency of airplanes as much as a whopping six percent, according to NASA.

That’s a major difference in cost, and could amount to millions when tallied across an entire fleet. That’s why, for the past few years, NASA has been working on a chemical coating that could prevent bug guts from getting stuck on the wings of planes and creating unnecessary drag. Though NASA first published a paper on the topic in 2013, it’s now testing five different coatings on a Boeing 757 to find out whether they work.

The name of the project sounds deceptively bureaucratic: Insect Accretion and Mitigation. It turns out that keeping bugs from getting stuck on planes is actually kind of a tough problem—one that’s plagued the aviation industry for decades. The problem isn’t just about creating a hydrophobic surface. The guts themselves are what create the problem, NASA explained a few years ago:

It’s not just water you have to deal with. “Yes, there’s a lot of water in a bug, but there’s also some biological components that actually impart the stickiness, and we have to deal with preventing those from sticking even though we know how to prevent water from sticking,” [Mia Siochi, of the Advanced Materials and Processing Branch at Langley] said.​

At Langley, the team says it uses something called a “bug gun” (use your imagination) to shoot bugs at test subjects in a wind tunnel at speeds of 150mph. Oh, you’d like to see a schematic of this gun? Here you go, courtesy of the study Engineered Surfaces for Mitigation of Insect Residue Adhesion:

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Suffice to say, the upcoming tests out in the wild are the result of years of testing and research. Last week, NASA announced it would be running a series of experiments on a 757 that it’s testing a number of other efficiency-oriented design changes on. To create a control group, it’ll measure how many bugs accumulate on the un-coated wings. Then, it’ll install five coated panels on the wings to see how they differ.

In the 2013 study, they counted incidences of “adhesion” a bit like a detective counts bullet holes:

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Only one question about their methodology remains. How did they pick where to test the coatings? NASA’s Kathy Barnstorff writes that the team “looked for the best bug-infested area in which to flight test the surfaces,” looking at 90 different airports. Out of all the bug-clogged runways in America, which provided the most splatter-y conditions? Shreveport.

http://www.engadget.com/2015/04/03/nasa-boeing-era-eco-friendly-planes/

NASA solving the worlds problems with a crap ton of engineering
 
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