Personally, rather than a Nick Fury book, I'd like to see a SHIELD book. A SHIELD book, by default, would have Nick Fury in it since he's been in SHIELD for just about all of it's existence. I'd like to see about a dozen main characters with three or four arcs per year, with running subplots that lead into the next arc.
And one SHIELD arc I would especially like to see, considering how Spider-man is becoming more active with other heros now, is one where Peter Parker gains a higher level access to SHIELD files.
Why, you may ask? Two reasons.
1. Because it would get the (apparently) obligatory Spider-Man guest appearance out of the way.
2. It would allow for a "flashback" arc starring
Richard and Mary Parker as SHIELD agents which I think is a great story waiting to happen. And Peter would be able to know a little more about his parents.