Since it appears likely that the Lizard will be the main villain in the first movie of the Reboot, I wonder if a) they will do the Origin or b) have a minor villain to fill out the first act while Dr. Connors is established... or c) they will go directly into Dr. Connors experimenting on the regrowth and quickly have the Lizard born, without a need for the first act filler.
Pros and Cons in any of these approaches IMO.
a) origin, been done before. But I would still love to see it done again, and better this time. Uncle Ben's death felt too PG for my liking, and as such.. lacked real impact. But to have the proper impact they need to utilize an actor of Martin Sheen's ability. If they go this route, I expect Uncle Ben and Aunt May's characters to be fleshed out more in flashbacks.
b) minor villain to fill out Act one. Pro - We get to see one of Spidey's lower level villains come to life on the screen. Like Rhino or Shocker. Always a plus, but (Con) with the limited budget (CGI included) I kind of doubt this, and would rather see them spend the money on getting the Lizard "right". Also, it would take away from the story/character development of the main players too.
c) Directly to Connors experimenting and transforming to the Lizard early on. Pro - If they handle it as a mystery and build the tension before the "money shot" of the Lizard this could be good. It would highten the suspense and help with the budget limitations as well. Con - It would mean little development of the bond between Peter and Dr. Connors, although they could flesh this out via flashbacks and interactions with the Connors clan and Peter after the fact.
It's gonna be interesting.. NO DOUBT.