Honestly, it's hard for me to call exactly which film will be the biggest next year. With Avengers, a lot relies on the Cap film. If Cap is Iron Man big, then the combined draw of seeing all these characters in one film will create huge pre-release buzz. And if the Avengers has some great spectacle a great story, it could be huge. That's what happened with TDK. It had huge pre-release buzz from the fact that the Joker was in it, and then even more once Ledger died. It got a huge crowd to the theaters opening week, and after that the quality of the film kept drawing them back. Avengers might be able to do that. Add that to the fact that when it comes to Nolan all bets are off. I sure as hell didn't expect Inception to do the numbers it did. I don't think many of us (if any) did. Riding off the good reception of Inception and being the sequel to TDK, this movie has the potential to still be huge.
The Hobbit obviously will be highly anticipated after the success of LOTR. So it could do very well.
And heck, Spider-man and Supes can't be counted out. However, since they're both on iffy standing in the general public because of their two previous movies being "meh" then it's hard to say. However with Spider-man, if he has some great trailers it will probably be big. Let's face it, even the worst Spider-man film still made bank. He's a moneymaking character. Supes might have a tougher time. But it's just really hard to predict.