Peter and Nathan aren't a family... they are related, they are *in* a family, but if you tell me you're going to introduce me to your family and you introduce your brother (especially if you have a wife and kids) then I'm going to give you the new fist pound.
While DL, Nikki and Micah are not technically the first Hero family to exist, (and I'm sure the Peterellis, Meri and Claire aren't either), they still are the nuclear family with superpowers, and the closest Heroes is ever going to get to "The Incredibles."
That said, somethiing Hiro's sister said struck me... she said "You're insane." And it struck me a bit odd. Later that day it hit me like a ton of bricks. When we first met Hiro, he was concentrating on a clock attempting to bend the space time continuum. What kind of MADMAN sits and tries to bend the space-time continuum? There are millions of comics lovers, many frequent these boards, but we don't EVER even for a SECOND consider actually trying to do any of the things that occur in comics. He had no evidence he could do any such thing, and between that and his sister's oddly innocent one liner, those are our first clues to Hiro's insanity. Yes, he can still function, he can still be a hero, but the idea that someone who's never even heard of anyone with powers would actually try and bend the space time continuum... He's gotta be bonkers.
Still one of my favorites, but I'm as sure that Hiro can bend Spacetime as I am that Isaac can control fate.