JQ says the soap opera element is missing. It doesn't seem like they've tried lately.
I'd like to see an old flame of MJ's show up to interview for a job at Stark Enterprises. He's just finished his Ph.D. (something Peter never did) and is brilliant. He doesn't have superpowers, though (kinda how Pete sometimes wishes he didn't). He and MJ go way back, maybe they dated in high school before she ever met Pete. But somehow things didn't work out (maybe his parents hated her or something). This guy could be like MJ's "Gwen" - the one that got away. He makes MJ - and Pete - wonder what life could have been like otherwise. For her, what if they hadn't broken up? Would she have become a model, etc? For Pete, this guy is what he could have been if he'd never been a superhero - a dedicated man of science who is about to be offered a $100K/year job. But to make matters more bizarre, Peter really likes the guy, and they become friends. I guess he could somehow fit in where Harry is now missing. Except this guy is still single (and since this is a visual medium, he'll be attractive, too) and can create a little tension with MJ once in a while.
How about that?