Apocalypse has healing powers similar to Wolverine. He can also alter all the molecules in his body (at least in the comics), hence the reason he can grow into gigantic sizes. Although I'm thinking he won't do that in reality--I think that might be an astral plane battle between him and Charles, which shows that these two will be fighting each other over something (my guess, control over Charles' body and telepathy).
I think Cerebro is going to be destroyed by Havoc, probably to sever the connection between Charles and Apocalypse (where Charles' eyes go black).
I don't think Apocalypse will need Cerebro; he can enhance mutant abilities. I think just having Charles, who is already the most powerful telepath, will be enough. But those are just my thoughts on it.