As was previously rumored, the popular insider confirmed the series will be a comedy and Jameela Jamil's Titania is serving as the main villain. Walsh revealed that, prior to her villainous origins, Titania is an "exercise guru on the internet" but "things aren’t working out, so she goes and sees a life coach" who turns out to be Tim Roth's Emil Blonsky aka Abomination.
According to Walsh, Abomination will obtain a sample of She-Hulk's blood and begin "passing it out as the cure-all to your life problems" which will "set up all the Hulks for what’s next." Supposedly, Blonsky's use of this sample will lead to the creation of many popular comic characters including Titania, Skaar, Thunderbolt Ross' Red Hulk, and "a bunch of loser dudes on a construction site" which creates the Wrecking Crew.
With so many Hulks introduced, the series will seemingly set the stage for the rumored World War Hulk movie as "Banner and Jen are like, 'What the f---?' We've got to bring this back down to Earth" and deal with the countless Hulks showing up.