Part of me is afraid it may come across as (or just straight up get turned into) just the mcu Suicide Squad, but if they really stick to the core of the comics it absolutely should be very different.
Suicide Squad comics are very much about terrible people doing good things, often because they're forced to, sometimes in exchange for something and very occasionally of their own volition, and there's a LOT of sudden turns and backstabbing, even teammembers killing each other and the stories often involve the squad being sent on super-dark missions that 'real heroes' like the Justice League would never agree to. (I recall one story that involved killing babies in order to prevent some kind of terrible biological outbreak.)
The Thunderbolts aren't supposed to be bad guys that are just forced/convinced to do good things and they don't usually do highly questionable black ops missions like the Squad do. The Thunderbolts are a straight up superhero team just like the Avengers or the X-Men, with the big difference that all the members used to be bad guys. But the focus of the whole series is very strongly on the idea of rehabilitation - who has truly rehabilitated themselves, who is faking it, who genuinely wants to rehabilitate but is really bad at it or just keeps having relapses, etc. And also on how society responds to villains that genuinely try to be better - can they be trusted, should they just be in prison or is that a waste of their potential to help, etc.
Unless, that is, they're not really doing the traditional Thunderbolts but are straight-up adapting Thunderbolt Ross's Thunderbolts instead - that was a completely different group and they were really just a bunch of semi-psychotic anti-heroes working together to help each other clear up some lose ends that they couldn't fix individually.
Because he's a pre-existing MCU villain the audience will recognize. Having people recognize the characters from previous movies and then seeing them try to become heroes instead would be an obvious way of adapting the Thunderbolts into the MCU (just like the original Thunderbolts were all characters that were already known as villains to the comics audience at the time, except Jolt). Presumably if he's on the team he'll probably use some sort of knock-off Iron Man technology, since that's what he's all about.