I will definitely get flamed for this, but I think, if done in the way they brought Dr. Octopus to the screen, with science behind it, my favorite Spider-Man villain would be a great choice for the next movie. Who am I talking about? Spot, of course. Think about it. He could work the same way Sandman did. An untouchable villain. Always slipping away, just out of reach. I know he's not really a top villain, but I think it could work, after all, he has awesome powers, and the special effect would be incredible.