I hope AoS spins off into something like the Secret Warriors. So I'd like to see a set up of that spread through the season. Individual character introductions and origins of the would be team. The Agents are out looking for more Inhumans to recruit or help, but come across non Inhuman enhanced beings as well. Creel's kid Jerry is introduced and discovered to have acquired his dad's abilities somehow. Robbie returns and takes the place of Hellfire. Explaining the origins of Phobos and Druid might be tricky, but they can pull it off somehow. Manifold is likely not an option to use, as he's a mutie. They can always invent a character to fill any void.
Perhaps by then Skrull will be fair game for the show, and the plot could involve them as well.
Perhaps by then Skrull will be fair game for the show, and the plot could involve them as well.