Aside from what everyone else has said, I’d really like them to go street level with the next film. Really make a statement on how this next trilogy differentiates itself from the previous one.
In that vein, I’d suggest using the Enforcers as the foes Spider-Man has to face. Have them start out as competent, above-average thugs that Spidey defeats the first time in the beginning of the film, but get hired by Kingpin and equipped with fancy tech to give themselves an edge. Since he’s alone and has to solve problems by himself now, what better problem for him to confront than a group of super thugs (plus, it would be neat to see the person who originally wanted to be an Avenger now as Public Enemy #1 facing off against a team of “superheroes”).
As far as members, Shocker and Scorpion would be great inclusions, since they were teased in Homecoming, as well as original comic book team members like Fancy Dan and Ox, since you need a competent hand to hand fighter and a heavy. Have the Tinkerer come back and be the one to give them their tech upgrades. Basically, it’s Kingpin trying to make a street level, Avengers-type group, but to stop Spider-Man. And, with Spidey’s public image tarnished, Fisk would have no problem getting approval.
Also, due to his current isolation, and the tease we got of the piece of the Symbiote left behind, we’ll probably see Peter struggle quite a bit emotionally and tap into his dark side. Maybe after the Enforcers, now with high-tech gear and weapons, get him in the rematch, he’s more tempted to use the symbiote to help him, since he’s probably kind of scared and still hasn’t quite figured out how to operate on his own. Also, I just want to see them do some recreation of the Black Suit Spidey vs Sinister Six fight from Spectacular Spider-Man, but with the Enforcers instead of the S6. Really show us what he could be capable if he didn’t hold back. Basically, the brutally and visceral nature of the Apartment fight in No Way Home x10, but more efficient and cold.
Black Cat could be interesting to have throughout as a foil to occasionally trip him up and the devil on Spidey’s shoulder slightly nudging him over to the dark side when he’s wearing the Black Suit. Having Daredevil in this could tie into Kingpin’s involvement with the Enforcers, as he’s trying bring down Fisk, so he and Spider-Man have to work a bit together at certain points to fight baddies or solve problems. Plus, it would be great for Matt Murdock, someone who has dealt with isolation from friends and struggled with not giving into his inner demons and going too far as a solo masked hero with a secret identity, to counsel Peter in his darkest moments and give him a new friend to talk to, just to let him know that it will be okay and that he’s not alone. The idea of “The Devil of Hell’s Kitchen” being the angel on Peter’s shoulder guiding him back to light is just too good to pass up.
Bring in Harry and Gwen as his new group of friends to make him a bit less lonely and bring just a bit of light back into his life after suffering so much loss in NWH. Gwen could be his intellectual equal and emotional confidant in his civilian life, and Harry could help him out a bit when in a bind, while also looking to Peter as kind of a big brother figure. Plus, with Gwen Stacy in the picture and Spider-Man as a “Menace”, Captain Stacy would be great for Spidey to have on the law side of things, possibly even help rehabilitate Spider-Man’s image. Maybe, after Spidey defeats the Enforcers at the end, Stacy reveals them for the crooks they really are, thus clearing the Wallcrawler’s name. Have Captain Stacy sort of be Spider-Man’s Commissioner Gordon, but more amiable.
(Did I mention I love Spectacular Spider-Man? ‘Cause I love Spectacular Spider-Man.)
Basically, use this film to establish the new status quo in regards to Spidey’s allies, his personal relationships, his adversaries and his relationship to the city as a solo superhero.