This was a good debate, much better than when he went against Palin, and much, much better than Obama Vs. Romney. Also funny to think how a lot of ppl here though Biden was going to be a gaffe machine, Biden's a debate man. He may gaffe in speeches, and get caught sleeping, but he brings his A game to debates.
Personally, I think Biden takes the win in nearly all areas. I agree his laughing came off as rude, but at the same time the VP debates are about being agressive, not being likeable. Biden beat Ryan on substance (again, IMO), came off stronger, and hit the zingers Obama can't if he wants to stay likeable. He mentioned 47% & 30%, "Let Detroit go bankrupt", brought the Ryan plan back into the spotlight, and showed his experience in the foreign policy areas. However I don't think it was a beating either. Ryan did hold his own for the most part, and should be proud of his performance. I don't think it was a blow out, but I do think Biden walks away with a clear win.
I think what Biden did tonight was reopen old wounds on the Romney camp, while stopping some of the bleeding on his own. Which I think is the most important thing he could have done. I also think Ryan did his camp a bit of diservice in the long run. He agreed with the Obama white house on two issues, saying the difference, more or less, would only be possible with a time machine. He also (thanks to the moderator) played into the fuzzy on the details image (which I blame more on the Romney campaign than Ryan).
As far as substance, that's a political thing. I just happen to line up more with Biden, and next to zilch with Ryan. So anything I say on that will be more opinion than an objective look at the debate. Plus the Ryan plan has been talked to death.