Family Business is one of my favorite comic series.
I would definitely be down for that 
		 
		
	 
Me too. Using Family Business as a storyline for a third film can remedy many of the issues with the last few films. 
1) The story could tie up the whole storyline with Peter's Parents, while introducing a Return of the Jedi type element of long lost Peter's sister. The CIA element actually fits perfectly with what May alluded to in ASM 2.
2) The story is a globe trotting adventure which can take Spiderman outside of The streets of New York for a change and allow the Spiderman character to have a foreign adventure which broadens its storytelling possibilities. TDK partially took place in China, The Wolverine took place in Japan, etc so its Superheroes globe trotting is not un heard of. The fish out of water aspect of the story also has its advantages for the Peter Parker character.
3) Teresa Parker offers a great opportunity to introduce a strong female lead who isn't another love interest and who is actually crucial to the plot. You also don't have to repeat the same tropes of Peter struggling with his love life yet again with a new MJ. Save the love interest for ASM 4 and have Peter be on the rebound . In fact , Woodley could play Teresa as opposed to MJ. 
4) Having a villain who also isn't bound to Oscorp and who isn't trying to destroy New York or whatever, but operates on a grander scale than Spiderman is use to on film would be another change from the previous films and could raise the stakes beyond lower Manhattan. A villain like Chameleon , who originally was a very international villain with the aid of henchmen like Sandman, Scorpion, Shocker etc. also breaks the trend of scientists and mentors who become Peter's villain , and instead can give us someone who is truly evil. 
5) The story could be something fresh while at the same time keeping itself tied to the other two films. It hasn't been done in a Spiderman film before and it opens up opportunities for storytelling that the other films didn't have.
6) With the central characters being Peter, Teresa, The Villain, and Peter's Parents , you have a much tighter narrative and a chance to tell a very personal story yet set against an international and global backdrop. 
While I think you'd have to change things from the comic , I think the structure could serve as a good foundation for a Spiderman film which isn't just a rehash of what all the other Spiderman films have done.