"Popular" was a poor choice of wording, perhaps. Not popular per se, but well-known & recognizable to most, including non-fans of either the comic or the series.
When Universal secured rights to 4 of Marvel's characters, they eventually adapted them all for TV. I have no idea why Dr. Strange was in that line up. Nothing against the character, mind you. He's a pretty cool dude, and a rather unique take on a 'superhero' at that; just not what I would have thought of when listing the top 4 characters. Actually I would have thought Iron Man would rank above the Doc, or Thor perhaps?
Anyhow... The Hulk comic inspired the TV show. The show inspired The Rampaging Hulk magazine, reprints of his TTA issues, and the 80's cartoon. Inspiration for the 90's cartoon is a little cloudier. I'd say as much or more straight from comics sales at the time as much as fans of the TV series (and their young kids). The '03 movie was a fairly safe gamble, due as much to the success of the comic book superhero genre on film (more or less) at the time. Everyone trotted out their heavy hitters first, for the most part. Blade was a surprise and probably did well because there was less pressure and no real expectations from either the film or comics industry and Blade fans; whose numbers are but a fraction of the X-Men / Hulk / Batman / Superman / Spider-Man fanbase. 1st, 2nd & 3rd generation Hulk comic fans and 1st and second generation TV show fans got the initial push into the theaters and were probably the most opposed as far as the material and their reaction to it. We all know that story.
Hopefully the makers of this 're-boot' have taken into account the fans from ALL incarnations and will pick the best of each version and weld them into a unique and satisfying new movie interpretation. To be successful they absolutely MUST maintain the core ideology behind the characters of both Banner AND the Hulk; their 'soul,' if you will. Also, they must get the Abomination character right, and not flonk his appearance up, the way Green Goblin was physically misinterpreted.
Based on previous CB movie experiences, I have as much negative energy as positive regarding this film at this point. But so far, each tidbit, no matter how small, I have found positively encouraging rather than making me feel like backsliding towards despair. Thankfully, I'm getting the same good vibes from both Iron Man and Dark Knight, too.
For Hulk fans of every incarnation - June 13th will make them really happy... or really disappointed. I honest-to-God hope that doesn't happen. He's my favorite comics character and deserves a truly great film of his own. I am hoping that the passion & talent behind and in front of the camera for this second go round will help insure that success.