Villains: KRAVEN THE HUNTER, DOCTOR OCTOPUS...and one other. Read to find out.
I would develop the Peter-Connors dynamic a bit. In a lab setting they would be studying the remains of the symbiote just to give us some closure on that. Meanwhile Aunt May begins seeing a new man and Peter tries to mend his relationship with Mary Jane. Sadly she just doesn't fell safe around him. She acknowledges that he is different from her, stronger and deep down she's not sure if he's truly human. For the first time she considers what his exposure to the genetically altered spider has yet to to do Parker. She doesn't like the possibilities. We get a scene where Spider-Man is webslinging and reflecting on Mary Jane's reluctance toward their wedding when he sees something below. He lands on the sidewalk and sees a furry pinned up in an alleyway with a letter pinned to the mask. Spidey inspects the letter which says "THE HUNT IS ON PARKER!"
Suddenly his Spider-Sense goes off and he ducks as a blade whizzes by his head. From the shadows steps KRAVEN THE HUNTER, wearing the pelt of some jungle beast. He effortlessly matches Spider-Man's punches and even lands a hit. He leaves Spider-Man immobilized by a poison dart in the alley. Eventually when the poison wears off he returns to his apartment and crashes on the couch. Just then the phone goes off; May is taking Peter and Mary Jane out to dinner with her and her new friend. That night we meet May's "new friend", an elderly gentleman in a wheelchair. As May is talking about Peter and Mary Jane's wedding, the body of a decapitated furry hits the glass of the restaurant window. Peter sense Kraven outside watching them. He excuses himself and suits up.
Outside he asks Kraven just what it is he wants. Kraven tells him that one of New York's most brilliant minds gave him access to the world's fiercest hunters: a crateful of Utah Velociraptor eggs. He just has to bring Spider-Man in alive. They fight and Spider-Man beats Kraven and Kraven is arrested. More Peter-Mary Jane fluff. The next day at college Gwen tells Peter that her father was badly wounded in a mass prison breakout. Spider-Man pays Captain Stacy a visit and learns that it was MONSTER that broke out Kraven. We find Kraven in an old warehouse near a large machine which hatches the Utah Velociraptor eggs. The MYSTERIOUS DOCTOR asks Kraven what he intends to do with his new toys. The Hunter smiles and tells him he's going to become an hero to the entire city.
Finally we find Mary Jane contemplating leaving New York for California. SHe's got the ticket and is still apprehensive about marrying Peter. That's when Aunt May arrives out front in a car and asks Mary Jane if she needs help picking out a wedding dress. She says she still has the one she was gonna marry John in. Aunt May asks her to come outside; she can tell something is wrong. Mary Jane tells Aunt May about her apprehensions, including that Peter is Spider-Man. Aunt May tells Mary Jane that she knew that already. They arrive at May's house. Inside May leads Mary Jane to the kitchen where her new friend is sitting with a cup of coffee and cake. He tells May to bring Peter as well. He ought to be there for the "talk." When May leaves the old man sets aside his newspaper and says "Remember me?" and grins; black tendrils of symbiote drip from beneath his eyes like tears. Mary Jane jumps up and tries to run, but a mechanical tentacle causes the door to cave in, trapping Mary Jane in the kitchen.
Peter meanwhile follows a SPIDER-TRACER he planted on Kraven. It leads him to a large building where he finds Kraven entereing via a the sewers. He follows him and engages one of the Utah Velociraptors in combat. Spider-Man impales it on a pipe and follows Kraven into the building. He confronts him in the bathroom and manages to smash all the toilets so the Raptors can't get in. They have a large fight that spills out into the CONVENTION CENTER right in the middle of Anthro-Con. Spider-Man tells the furries that Kraven is responsible for the murder of their fellow furries. Spider-Man disarms them and leaves as the furries begin yiffing Kraven to death. Outside he finds Aunt May waiting. She tells him that Mary Jane is waiting for him at her apartment. As they drive off, we see a series of reptillian/saurian forms entereing the CONVENTION CENTER through the front doors.
Back at the apartment Spider-Man quickly unblocks the collapsed doorway and finds Mary Jane tied to the ceiling fan, hanging from a noose of BLACK WEBBING. Spider-Man runs to her and cuts her down. Suddenly a form throws itself at Spider-Man. He sees it is AUNT MAY, with some BLACK SUBSTANCE dripping from her mouth. He throws her off and binds her with webbing. He does the same for Mary Jane who is leaking BLACK SUBSTANCE from her eyes. Suddenly a dark form crashes through the ceiling....OTTO OCTAVIOUS! He tells Spider-Man that a piece of the symbiote found him beneath the waves and reanimated him. He is now Dr. Venopuss! They fight and Spider-Man manages to kill him by kicking him through the street and into the sewers where the Utah Velociraptors procede to tear him to shreds.
As Peter Parker, he rushes the symbiote zombie Aunt May and Mary Jane to Doctor Connors...but he isn't there and the lab is totally demolished. He puts zombie Aunt May and zombie Mary Jane into a locker and locks it, and reinforces it with webbing. He leaves a letter on there cautioning others against opening it and signs it "COURTESY YOUR FRIENDLY NEIGHBORHOOD SPIDER-MAN." Afterward in the wreckage he finds a set of TRACKS.
With that he swings off into the night following the saurian tracks from the lab.
END.