Titles I'd like to see:
A Thing solo book. My favorite member of the FF, and he's worked well solo before in MTIO and assorted series and minis over the years. Comics are seriously lacking in quality beat 'em ups anymore, so why not do something like that with him in it again.
Moon Knight would be cool, but how many people here actually liked Moon Knight before? Was never that popular a character, and past attempts at this guy have all met the same fate. He does look cool, though, and that alone warrents a title in my book. Loved the first series back in the early 80's, late 70's. Good stuff.
I like the current Nightcrawler series going on, and wouldn't mind seeing something like this for Kitty Pryde. My favorite X-Man by far, she's been in some decent minis over the years as well, so that could work for a solo title. Plus, she' smart, can walk through walls, AND has a pet dragon. What's not to like?
I'd love to see a title completely from the villains perspective. And not like Thunderbolts, but real villains, doing villain things. Like Dr. Doom or Red Skull. Or even a book about B-list villains like the Wrecking Crew. In fact, especially a book about B-listers like the Wrecking Crew. What is it that keeps driving these guys? Why do they need to do what they do? And how they keep escaping custody? Really, the Wrecking Crew will show up in like five different books over the course of a year, get soundly thrashed in every one of them, but still come back for more. Or when a villain like Whiplash gets beat by Iron Man, he's sent off to jail. So how does he get out? Where does he find new whips? Why bother with the life-of-crime thing if he's getting bounced every time? And why whips of all things? That sort of thing. Nagging questions that keep me up at night.
Others already mentioned:
Power Man and Iron Fist? Ok, but been tried a bunch of times now too. Their original title was ok at times, brutal at others. Past attempts at re-launching it has met with disappointment once the novelty wears off. Even updating them past their kitchy "blaxploitation meets kung-fu" origins doesn't help much.
Ditto Fury. Always liked Nick Fury, but he's better off as a role character, someone who sets actions into motion. If they wanted to do something more from the SHIELD end of things, that could work. It's kind of hokey watching Fury lead the charge into battle, or do the whole James Bond thing now. Since he's the head of this huge organization, he's not likely to be the one jumping out of planes or leading a covert missions himself. Introduce some new characters, have Fury be the one giving them orders, but otherwise keep him on the sidelines. Like others here, SHIELD interests me more than Fury alone.