I don't think it's coincidence that these 5 teams or heroes have the biggest movie franchises and some of the most successful runs in comic book history. They all have great villain line-ups and you can trace many villain storylines in other books to these original five. However, if you don't agree with the choices, simply pick "other" and give us your choice. X-Men -- Magneto, Apocalypse, Mister Sinister, Hellfire Club, Mystique, Sabretooth, Juggernaught, Dark Phoenix, etc. Batman -- Joker, Riddler, Penguin, Catwoman, Poison Ivy, Bane, Two Face, Ra's Al Ghul, etc. Superman -- Lex Luthor, Doomsday, Brainiac, Bizarro, General Zod, Darkseid, Mr. Mxyzptlk, etc. Spider-Man -- Green Goblin, Kraven, Venom, Carnage, Doctor Octopus, Lizard, Scorpion, Rhino, Kingpin, Hobgoblin, Electro, Sandman, etc. Fantastic Four -- Galactus, Thanos, Skrulls, Doctor Doom, Terrax, Mole Man, etc. Other choices? Daredevil has some cool enemies, although many spawn off from the Spider-Man storylines. Green Lantern has Sinestro. Justice League has some nifty enemies, although many relate to Superman. Hulk has some original bad guys.