I'm not an expert on comedy directors, or directors in general, but how about some people Rudd or Douglas have worked with before?
*Jon Turtletaub --- National Treasure, The Sorcerer's Apprentice, Cool Runnings, and Last Vegas (which starred Michael Douglas). Turtletaub is a veteran Disney go-to guy.
*David Wain --- Role Models (which starred Rudd), and a lot of Adult Swim/Cartoon Network fare, including Children's Hospital, Tim and Eric, Mad TV, and The State.
*Jay Roach --- Dinner for Schmucks (starred Rudd), The Focker series, the Sacha Baron Cohen films. Dude knows comedy, and quirk.
*Judd Apatow, or Seth Rogen --- Rudd is a long-term member of the Apatow/Rogen Brat Pack. Putting one (or both) in charge or Rudd as a superhero called "Ant-Man" seems like....I dunno, destiny. Plus, Apatow is currently directing a fittingly named movie right now called "Trainwreck."