Probably right. Tho hopefully the show wont waste too much time with a mopey guilt ridden Fitz. He is in a glorified virtual reality videogame. Him doing horrible **** to fake Framework people isnt much different from any video gamers killing NPCs in GTA or Assassin's Creed or Uncharted or any other video game. Killing real people is about the only thing that should boher him, but even that is a result of Aida's tampering with his brain and memories. Everything he did in the Framework was Aida's fault. She made Framework Fitz. Real Fitz is innocent in all this.
I agree "Real" Fitz should (very probably; details about the changes would help) not feel guilty when he's back because that was Framework Fitz, I don't think the real victims vs. framework victims distinction is relevant from the perspective of moral blameworthiness, for the following reasons:
1. People who play video games know that they're playing video games. Framework Fitz does not, and has no reason to believe he is.
If someone is placed in a framework but their memories are not altered, and they shoot and kill a framework person without good reason, they're as guilty as if they had shot and killed a real person outside the framework, even granting for the sake of the argument that framework people are not real - because the killer does not have any information telling him that.
In fact, I would say that Framework Fitz, if he's making his own choices, is also guilty of murder, torture, etc.; but that would not make "real-world" Fitz guilty.
2. It's at least unclear that framework people aren't people. I would further say they very probably are people. Jemma seems to have begun realizing that. Why would they not be real? They don't have human brains, sure. But a human brain is not required for consciousness or self-awareness. It's very probable that Aida is self-aware - given behavior -, but she has a computer for a brain, so why not framework people?
One could argue they're not real because there isn't enough computing power, but given their human-like behavior, it seems to me there is, at least for some of them (even if the rest of the framework is filled with non-persons due to insufficient computing power, framework Agnes or framework Radcliffe have full range of human behavior; probably the same goes for framework Mack's kid, framework's Ward, and all of those interacting daily and very closely with people, since they have to behave like people to pass for people; that might or might not extend to the whole framework).
I guess we can't be certain that human-like behavior requires self-awareness in the Marvel universe, but it seems very probable (at least, in absence of evidence to the contrary).
3. You're implying that Aida and Radcliffe are guilty. I do agree, but Aida does not have a human brain, and neither does Radcliffe after Aida killed him outside the framework.