Isn't it basically the same deal as Secret Invasion, then? Secret Invasion is, at its core, just an alien invasion story. Bendis is going continuity-crazy in New Avengers and Mighty Avengers, but you don't really need to know any of that to enjoy Secret Invasion. The plot is actually pretty simple and continuity-free: shapeshifting religious zealots from another planet infiltrate and attack Earth while Earth's heroes are wrapped up in their own problems. Does it enrich the story to know that Earth has had previous dealings with the Skrulls, that various characters were replaced at very specific times, that the Skrulls may or may not have had a role to play in various other things? Sure. But it's not necessary to enjoy the story.
Yeah.
To be honest it was the avengers titles i had in mind as being less accessible than 616