Relax. We have known this for awhile. He's gonna get relaunched...like every other high selling Marvel Now book.
http://www.bleedingcool.com/2014/10/28/deadpool-to-relaunch-in-2015/
But would that be the end? No. You may be getting Death Of Deadpool story leading up to #250 to parody the Death Of Wolverine series, but straight afterwards, there will be a Deadpool #1 again.
They’re not daft.
They have a Death of Deadpool storyline in every Vol of Deadpool comics, and the character of Death is literally in love with him cause he can't die. This has been there since Joe Kellys run. What sucks is that Gerry Duggan is more then likely leaving Deadpool after this. This Vol has been some of the best Deadpool material out there.
As for Wolverine, come on. So Marvel can kill Spider-Man (616 and Ultimate) and Nova (Rider), replace Thor and Cap, but they can't do that to Wolverine because his film rights are owned by Fox? Makes no sense. He'll be back just as Parker is. Take a look at the top 10 selling comics of 2014. Death Of Wolverine was #4, 5, 8 and 9. Now take a guess at how much "The Return Of Wolverine" #1 will make. That book was a huge win for Marvel and just boosted his popularity and demand in comics. Which is what they want cause lets face it, X-Men fans love to complain about Wolverine getting too much focus. Only marvel books to sell more were Amazing Spidey #1 and Rocket #1.
Plenty of books have been cancelled and relaunched other then current Fox film titles. Cap, Thor, Hawkeye, Daredevil and Amazing Spider-Man have all been relaunched post original Marvel Now launch. While Avengers Undercover, Secret Avengers, Ghost Rider, X-Force, She Hulk and Invaders were/are getting cancelled. If a book doesn't sell you can very well blame the fans cause they are not buying it. Can't blame Marvel for cancelling a book that nobody is buying. Deadpool is pretty much the longest running title at Marvel Now, which shows you how things have changed in the past 5 years and how well he sells for them. Not too mention his other minis and countless Variant covers for other titles.
Now regarding Wanda and Pietro, I got nothing. Not a fan of that choice and I hope they don't go the Inhuman route. But it's a move for their benefit, not to piss off Fox.