Think about this for a moment....what is the chances that Norman Osborn already know that Peter Parker is Spider-Man? Curt Conners knows that Peter is Spidey. The Man is the Shadows(MitS) apparently sees Peter as a threat, given his tremendous interest & concern on what Connors have told "the boy" of his parents. Is it possible, we didn't see all of the exchange(debriefing)...may have Connors told the MitS that the boy is Spider-Man? Prompting Connors to warn the MitS, "You should leave him alone." Do the MitS now realize the implications of Peter being the only successful "Cross-Genectic Experiment(although accidental)?" Which may prompt the MitS hope for a cure of Norman's apparently terminal disease? Which leads to the fact that Peter does not know, does not have a clue, that he has a deadly and venerable enemy.