The Lana they have in the new 52 is the best version of the character in any medium IMO. She's a smart, good hearted engineer who trots around the globe, going into hot areas and volunteering her expertise.
I can totally see the heroic, globe trotting lana connecting with the superheroic glob trotting CK/superman who also happens to be boy who saved her life back in Smallville. Basically two heroes finding common ground.
What I don't want to see is a love triangle between lana, lois and Clark because that would be cheesy and cliched (the pre-crisis comics milked that story to death).
As for Michelle Monaghan, well she's always been my pick for Lois but I really like her in any role and would welcome her as lana.