The
Ultimate Marvel version of Mysterio was introduced in
Ultimate Spider-Man Annual #3. His appearance is drastically changed from his 616 counterpart. He wears all black with a green neck brace that produces blue smoke that envelopes his face. In his first appearance, he had a police technician to set up surveillance equipment to the police department. However, after NYPD's police captain Frank Quaid asked Spider-Man to aid them to find the crook who was somehow able to stay ahead of his unit.
Mary Jane Watson, Spider-Man's love interest, figured out how the criminal does it after the hero informed her of the situation. After the police arrested his
accomplice, the villain vowed to get even with Spider-Man and then escapes.
[73]
Mysterio appears again in
Ultimate Comics Spider-Man #1, blasting Kingpin out the window of a skyscraper.
[74] He publicly confesses to Wilson Fisk's murder and threatens the city, stating that he is now in charge. He releases a fear hallucinogen across Manhattan in order to rob the Federal Bank. Spider-Man stops him and Mysterio's personal hatred for the web slinger increases.
[75]
Creating an illusion of the Hulk to lure Spider-Man to him, Mysterio ambushes and severely wounds the hero. Before Mysterio can unmask and kill Spider-Man, a
mysterious vigilanterescues him and together they defeat Mysterio, revealing his true face. Mysterio finds Spidey's blood on his broken armor and designs a Spider-Slayer that personally targets Peter. Spider-Man defeats it, and before Mysterio can do anything else, the police rush to his hideout, which they found by tracking a piece of Mysterio's tech. Mysterio curses and proceeds to blow up his hideout.
[76]
It was revealed in Spider-Men that this reality's Mysterio is a simple android, remotely controlled in real time by an 'avatar' program that was created and sent forth by the Earth-616 Mysterio in order to conquer the Earth of the Ultimate Marvel universe.